Medication Nation

Nutritional Supplements: Amino Acids

By Kimberly Read & Marcia Purse, About.com

Updated: July 30, 2006

Research indicates there are a number of supplements which may be beneficial for those with this disorder. I have categorized these into amino acids, vitamins and minerals. In this first article we will explore the amino acids. However, a note of caution before we begin.

The purpose of this article is to bring these supplements to your attention so that you may be aware of some additional tools available for your well-being. This article is intended as a source of information to discuss with your doctor and not as a replacement for your doctor. These supplements are just that - supplements. They can in no way replace your prescription medications for manic depression.

Amino Acid Defined

A literal definition of an Amino acid is an organic compound containing an amino group (-NH2) and a carboxyl group (-COOH). So what does this mean? It means they are literally the building blocks for all life, in that they are the chemical basis for all protein. Protein is one of the biggest components of our bodies (as well as the bodies of all living things). Our bodies use amino acids to form the proteins which build everything from muscles and bones, skin and hair, to internal organs and fluids. These amino acids also play an active role in our nervous system, where they function as neurotransmitters carrying messages from cell to cell. In short, amino acids are absolutely essential for our well-being. (For additional reading about the science of amino acids, take a look at The Amino Acid Collection and Amino Acids - An Overview.)

There are about 20 natural amino acids. These can be divided into two basic groups: essential and nonessential. The essential amino acids are those which your body cannot synthesize. Your body only gets these through your diet. The nonessential amino acids are just as important, but your liver can manufacture them.

Amino Acids and Bipolar Disorder

As it relates to Bipolar Disorder, an overall balance of amino acids is very important. This gives the body a healthy supply of protein which is necessary for normal brain function as well as helping combat depression. In the book Prescription for Nutritional Healing, the authors recommend taking, as directed on the label, a free-form amino acid complex twice daily on an empty stomach.

Two in Particular

In considering specific amino acids as supplements for those with Bipolar Disorder, two in particular may be of some help. Tyrosine transmits nerve impulses to the brain, helps overcome depression, improves memory and increases mental alertness among other things. Tyrosine supports the formation of the bulk of neurotransmitters in the body. A reduction in neurotransmitters such as dopamine, norepinephrine and epinephrine can lead to fatigue and even depression.

Athletic Nutrition.com (link no longer available) pointed out that there are no definitive studies as to an effective dosage for Tyrosine. However, Prescription for Nutritional Healing recommends 500 mg three times a day on an empty stomach. This book also warns that Tyrosine should NOT be taken if you are taking an MAO inhibitor.

Taurine is another which has possibilities for helping with Bipolar Disorder, in that it can reduce hyperactivity and anxiety. Taurine is an inhibitory neurotransmitter and therefore functions as a mild sedative. The Natural Health Consultants recommend one 1,000 mg dose a day. AMNI (Advanced Medical Nutrition) [link no longer available] stated that 500 mg up to 3 times a day may be taken. You should be aware that excessive levels can lead to depression and short term memory loss.

In closing, I just want to remind you to consult your doctor before taking any nutritional supplements. The individual amino acids in particular should only be taken under the supervision of a medical professional.